Article
A novel insulin receptor substrate protein, xIRS-u, potentiates insulin signaling: functional importance of its pleckstrin homology domain.
Molecular endocrinology (Baltimore, Md.) - 1 Aug 1998
Ohan N, Bayaa M, Kumar P, Zhu L, Liu X J
Abstract excerpt
A novel Xenopus insulin receptor substrate cDNA was isolated by hybridization screening using the rat insulin receptor substrate-1 (IRS-1) cDNA as a probe. The xIRS-u cDNA encodes an open reading frame of 1003 amino acids including a putative amino-terminal pleckstrin homology (PH) domain and pho...
Topics
- Adaptor Proteins, Signal Transducing
- Amino Acid Sequence
- Animals
- Base Sequence
- Binding Sites
- Blood Proteins
- Calcium-Calmodulin-Dependent Protein Kinases
- Cloning, Molecular
- Female
- GRB2 Adaptor Protein
- Insulin
- Insulin Receptor Substrate Proteins
- Molecular Sequence Data
- Mutation
- Oocytes
- Phosphatidylinositol 3-Kinases
- Phosphoproteins
- Proteins