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Article

Structural and biochemical characterization of the KRLB region in insulin receptor substrate-2.

Nature structural & molecular biology - 1 Mar 2008

Wu Jinhua, Tseng Yolanda D, Xu Chong-Feng, Neubert Thomas A, White Morris F, Hubbard Stevan R

Abstract excerpt

Insulin receptor substrates 1 and 2 (IRS1 and -2) are crucial adaptor proteins in mediating the metabolic and mitogenic effects of insulin and insulin-like growth factor 1. These proteins consist of a pleckstrin homology domain, a phosphotyrosine binding domain and a C-terminal region containing numerous sites of tyrosine, serine and threonine phosphorylation. Previous yeast two-hybrid studies identified a region...

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Source

Identifiers

PMID: 18278056
DOI: 10.1038/nsmb.1388

Genes

IRS2
IRS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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