Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Osmotic stress inhibits p70/85 S6 kinase through activation of a protein phosphatase.

The Journal of biological chemistry - 27 Aug 1999

Parrott L A, Templeton D J

Abstract excerpt

While studying the stress regulation of p70/85 S6 kinase (S6K), we observed that anisomycin and UV light stimulated S6K activity, but that sorbitol inactivated S6K. Pretreatment with hyperosmotic stress also prevented the activation of S6K by both 12-O-tetradecanoylphorbol-13-acetate and anisomycin. Comparison of sorbitol and rapamycin revealed that both agents inactivated S6K and caused dephosphorylation of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chlorocebus aethiops
Share to Marine Toxins
Share to Osmotic Pressure

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Oxazoles

Share to Phosphoprotein Phosphatases

Share to Ribosomal Protein S6 Kinases

Share to Sirolimus

Share to Ultraviolet Rays

Source

Identifiers

PMID: 10455142
DOI: 10.1074/jbc.274.35.24731

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Osmotic stress inhibits p70/85 S6 kinase through activation of a protein phosphatase.PMID 10455142Read ↗

Structural and functional analysis of pp70S6k.Semantic proximity Read ↗

S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5'-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway.Semantic proximity Read ↗

Protein Kinase R Mediates the Inflammatory Response Induced by Hyperosmotic Stress.Semantic proximity Read ↗

A new role for the p85-phosphatidylinositol 3-kinase regulatory subunit linking FRAP to p70 S6 kinase activation.Semantic proximity Read ↗

Inhibition of mammalian target of rapamycin activates apoptosis signal-regulating kinase 1 signaling by suppressing protein phosphatase 5 activity.Semantic proximity Read ↗

Protein phosphatase 2C is responsible for VP-induced dephosphorylation of AQP2 serine 261.Semantic proximity Read ↗

RAS/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation.Semantic proximity Read ↗

Osmotic stimulation of the Na+/H+ exchanger NHE1: relationship to the activation of three MAPK pathways.Semantic proximity Read ↗

Rapamycin selectively inhibits angiotensin II-induced increase in protein synthesis in cardiac myocytes in vitro. Potential role of 70-kD S6 kinase in angiotensin II-induced cardiac hypertrophy.Semantic proximity Read ↗

Requirement of the serine-threonine kinase Akt for heat treatment-induced activation of p70 S6 kinase.Semantic proximity Read ↗

Inhibition of v-Mos kinase activity by protein kinase A.Semantic proximity Read ↗

Induction of mitogen-activated protein kinase phosphatase 1 by the stress-activated protein kinase signaling pathway but not by extracellular signal-regulated kinase in fibroblasts.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.