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Article

Osmotic stimulation of the Na+/H+ exchanger NHE1: relationship to the activation of three MAPK pathways.

The Journal of membrane biology - 1 Jun 2001

Gillis D, Shrode L D, Krump E, Howard C M, Rubie E A, Tibbles L A, Woodgett J, Grinstein S

Abstract excerpt

The Na+/H+ exchanger (NHE) becomes activated by hyperosmolar stress, thereby contributing to cell volume regulation. The signaling pathway(s) responsible for the shrinkage-induced activation of NHE, however, remain unknown. A family of mitogen-activated protein kinases (MAPK), encompassing p42/p44 Erk, p38 MAPK and SAPK, has been implicated in a variety of cellular responses to changes in osmolarity. We therefore...

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PMID: 11420607
DOI: 10.1007/s00232-001-0023-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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