Article
Rapamycin selectively inhibits angiotensin II-induced increase in protein synthesis in cardiac myocytes in vitro. Potential role of 70-kD S6 kinase in angiotensin II-induced cardiac hypertrophy.
Circulation research - 1 Dec 1995
Sadoshima J, Izumo S
Abstract excerpt
It has been suggested that phosphorylation of a 40S ribosomal protein, S6, regulates protein synthesis. Two distinct families of S6 kinase have been identified, the rsk-encoded 85- to 92-kD S6 kinase (RSK) and the 70- or 85-kD S6 kinase (p70S6K). We have previously shown that hypertrophic stimuli...
Topics
- Analysis of Variance
- Angiotensin II
- Animals
- Anti-Bacterial Agents
- Cardiomegaly
- Cells, Cultured
- Enzyme Activation
- Genes, fos
- Immunoblotting
- Muscle Proteins
- Myocardium
- Phenotype
- Phosphorylation
- Polyenes
- Precipitin Tests
- Protein Biosynthesis
- Protein Serine-Threonine Kinases
- Radioimmunoassay