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Article

Inhibition of mammalian target of rapamycin activates apoptosis signal-regulating kinase 1 signaling by suppressing protein phosphatase 5 activity.

The Journal of biological chemistry - 27 Aug 2004

Huang Shile, Shu Lili, Easton John, Harwood Franklin C, Germain Glen S, Ichijo Hidenori, Houghton Peter J

Abstract excerpt

Under serum-free conditions, rapamycin, an inhibitor of mammalian target of rapamycin (mTOR), induces a cellular stress response characterized by rapid and sustained activation of the apoptosis signal-regulating kinase 1 (ASK1) signaling pathway and selective apoptosis of cells lacking functional...

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Identifiers

PMID: 15218033
DOI: 10.1074/jbc.M401208200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15218033-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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