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Article

Protein phosphatase 2C is responsible for VP-induced dephosphorylation of AQP2 serine 261.

American journal of physiology. Renal physiology - 1 Aug 2017

Cheung Pui W, Ueberdiek Lars, Day Jack, Bouley Richard, Brown Dennis

Abstract excerpt

Aquaporin 2 (AQP2) trafficking is regulated by phosphorylation and dephosphorylation of serine residues in the AQP2 COOH terminus. Vasopressin (VP) binding to its receptor (V2R) leads to a cascade of events that result in phosphorylation of serine 256 (S256), S264, and S269, but dephosphorylation of S261. To identify which phosphatase is responsible for VP-induced S261 dephosphorylation, we pretreated cells with...

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Source

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Identifiers

PMID: 28381458
DOI: 10.1152/ajprenal.00004.2017
PMCID: PMC5582913

Genes

AQP2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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