Article
Protein Kinase R Mediates the Inflammatory Response Induced by Hyperosmotic Stress.
Molecular and cellular biology - 15 Feb 2017
Farabaugh Kenneth T, Majumder Mithu, Guan Bo-Jhih, Jobava Raul, Wu Jing, Krokowski Dawid, Gao Xing-Huang, Schuster Andrew, Longworth Michelle, Chan Edward D, Bianchi Massimiliano, Dey Madhusudan, Koromilas Antonis E, Ramakrishnan Parameswaran, Hatzoglou Maria
Abstract excerpt
High extracellular osmolarity results in a switch from an adaptive to an inflammatory gene expression program. We show that hyperosmotic stress activates the protein kinase R (PKR) independently of its RNA-binding domain. In turn, PKR stimulates nuclear accumulation of nuclear factor κB (NF-κB) p65 species phosphorylated at serine-536, which is paralleled by the induction of a subset of inflammatory NF-κB...
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