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Article

The role of phosphatidylinositol 3-kinase, rho family GTPases, and STAT3 in Ros-induced cell transformation.

The Journal of biological chemistry - 29 Mar 2002

Nguyen Kevin T, Zong Cong S, Uttamsingh Shailaja, Sachdev Pallavi, Bhanot Monica, Le Mai-Thao, Chan Joseph L-K, Wang Lu-Hai

Abstract excerpt

Using loss-of-function mutants of Ros and inducible epidermal growth factor receptor-Ros chimeras we investigated the role of various signaling pathways in Ros-induced cell transformation. Inhibition of the mitogen-activated protein kinase (MAPK) pathway with the MEK (MAP/extracellular signal-regulated kinase kinase) inhibitor PD98059 had little effect on the Ros-induced monolayer and anchorage-independent growth...

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Identifiers

PMID: 11799110
DOI: 10.1074/jbc.M108166200

Genes

STAT3
PTEN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The role of phosphatidylinositol 3-kinase, rho family GTPases, and STAT3 in Ros-induced cell transformation.PMID 11799110Read ↗

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