Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Role of MLK3-mediated activation of p70 S6 kinase in Rac1 transformation.

The Journal of biological chemistry - 15 Feb 2002

Lambert John M, Karnoub Antoine E, Graves Lee M, Campbell Sharon L, Der Channing J

Abstract excerpt

The signaling pathways that mediate the transforming activity of the Rac1 GTPase remain to be determined. In the present study, we used effector domain mutants of the constitutively activated Rac(61L) mutant that display differential transforming activities and differential activation of downstream effector pathways to investigate the contribution of p70 S6 kinase (p70(S6K)) to Rac1 transformation and to decipher...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3T3 Cells
Share to Agar
Share to Luciferases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to MAP Kinase Kinase Kinases

Share to Mitogen-Activated Protein Kinase 8

Share to Precipitin Tests

Share to rac1 GTP-Binding Protein

Share to Ribosomal Protein S6 Kinases

Source

Identifiers

PMID: 11713255
DOI: 10.1074/jbc.M109379200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of MLK3-mediated activation of p70 S6 kinase in Rac1 transformation.PMID 11713255Read ↗

Differential roles of Akt, Rac, and Ral in R-Ras-mediated cellular transformation, adhesion, and survival.Semantic proximity Read ↗

The 70 kDa S6 kinase complexes with and is activated by the Rho family G proteins Cdc42 and Rac1.Semantic proximity Read ↗

Serine-71 phosphorylation of Rac1 modulates downstream signaling.Semantic proximity Read ↗

A role of STAT3 in Rho GTPase-regulated cell migration and proliferation.Semantic proximity Read ↗

The JNK/SAPK activator mixed lineage kinase 3 (MLK3) transforms NIH 3T3 cells in a MEK-dependent fashion.Semantic proximity Read ↗

R-Ras is regulated by activators and effectors distinct from those that control Ras function.Semantic proximity Read ↗

Kinase-deficient Pak1 mutants inhibit Ras transformation of Rat-1 fibroblasts.Semantic proximity Read ↗

Activation of the JNK pathway is essential for transformation by the Met oncogene.Semantic proximity Read ↗

Phosphoregulation of mixed-lineage kinase 1 activity by multiple phosphorylation in the activation loop.Semantic proximity Read ↗

Activation of p70/p85 S6 kinase by a pathway independent of p21ras.Semantic proximity Read ↗

Regulation of p70 S6 kinase by complex formation between the Rac guanine nucleotide exchange factor (Rac-GEF) Tiam1 and the scaffold spinophilin.Semantic proximity Read ↗

Regulation of STAT3 by direct binding to the Rac1 GTPase.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.