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Article

The G2 Checkpoint Is Maintained by Redundant Pathways

1 Sept 1999

Abstract excerpt

While p53 activity is critical for a DNA damage-induced G(1) checkpoint, its role in the G(2) checkpoint has not been compelling because cells lacking p53 retain the ability to arrest in G(2) following DNA damage. Comparison between normal human foreskin fibroblasts (HFFs) and HFFs in which p53 was eliminated by transduction with human papillomavirus type 16 E6 showed that treatment with adriamycin initiated...

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Identifiers

PMID: 10454534
DOI: 10.1128/mcb.19.9.5872

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