Article
Population studies of the human V kappa A18 gene polymorphism in Caucasians, blacks and Eskimos. New functional alleles and evidence for evolutionary selection of a more restricted antibody repertoire.
Tissue antigens - 1 Jun 1997
Juul L, Hougs L, Andersen V, Garred P, Ryder L, Svejgaard A, Høgh B, Lamm L, Graugaard B, Barington T
Abstract excerpt
Immunoglobulin gene polymorphisms are interesting because they reflect differences in the available antibody repertoire which may affect the susceptibility to specific infections. Until recently, the human V kappa gene, A18, was known as a nonfunctional gene only. In this study, we cloned and sequenced four apparently functional alleles and determined the gene frequencies in three well-defined populations: Danish...
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