Article
Suppression of prostate cancer invasive potential and matrix metalloproteinase activity by E-cadherin transfection.
Cancer research - 1 Aug 1999
Luo J, Lubaroff D M, Hendrix M J
Abstract excerpt
Our previous studies have demonstrated the heterogeneous expression of E-cadherin in a Dunning rat prostate tumor model. From this model, cloned E-cadherin-negative cells exhibited enhanced invasive and metastatic potential when compared with E-cadherin-positive cells. In this report, we examined the invasion suppressor function of E-cadherin in these prostate tumor cell clones. The E-cadherin gene was stably...
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