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Article

Suppression of prostate cancer invasive potential and matrix metalloproteinase activity by E-cadherin transfection.

Cancer research - 1 Aug 1999

Luo J, Lubaroff D M, Hendrix M J

Abstract excerpt

Our previous studies have demonstrated the heterogeneous expression of E-cadherin in a Dunning rat prostate tumor model. From this model, cloned E-cadherin-negative cells exhibited enhanced invasive and metastatic potential when compared with E-cadherin-positive cells. In this report, we examined the invasion suppressor function of E-cadherin in these prostate tumor cell clones. The E-cadherin gene was stably...

Topics

Adenocarcinoma
Animals
Cadherins
Enzyme Induction
Gelatinases
Male
Matrix Metalloproteinase 2
Metalloendopeptidases
Neoplasm Invasiveness
Neoplasm Proteins
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Prostatic Neoplasms

Rats

Recombinant Fusion Proteins

Transfection

Tumor Cells, Cultured

Source

Identifiers

PMID: 10446959

Provenance

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