Article
Induction of polarized cell-cell association and retardation of growth by activation of the E-cadherin-catenin adhesion system in a dispersed carcinoma line.
The Journal of cell biology - 1 Oct 1994
Watabe M, Nagafuchi A, Tsukita S, Takeichi M
Abstract excerpt
PC9 lung carcinoma cells cannot tightly associate with one another, and therefore grow singly, despite their expression of E-cadherin, because of their lack of alpha-catenin, a cadherin-associated protein. However, when the E-cadherin is activated by transfection with alpha-catenin cDNA, they form spherical aggregates, each consisting of an enclosed monolayer cell sheet. In the present work, we examined whether...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.