Article
Induction of polarized cell-cell association and retardation of growth by activation of the E-cadherin-catenin adhesion system in a dispersed carcinoma line.
The Journal of cell biology - 1 Oct 1994
Watabe M, Nagafuchi A, Tsukita S, Takeichi M
Abstract excerpt
PC9 lung carcinoma cells cannot tightly associate with one another, and therefore grow singly, despite their expression of E-cadherin, because of their lack of alpha-catenin, a cadherin-associated protein. However, when the E-cadherin is activated by transfection with alpha-catenin cDNA, they for...
Topics
- Cadherins
- Cell Adhesion
- Cell Adhesion Molecules
- Cell Division
- Cell Polarity
- Cytoskeletal Proteins
- DNA, Complementary
- Epithelial Cells
- Humans
- Integrins
- Intercellular Junctions
- Laminin
- Membrane Proteins
- Phenotype
- Phosphoproteins
- Transfection
- Tumor Cells, Cultured
- Zonula Occludens-1 Protein