Article
E-cadherin expression: a counterbalance for cancer cell invasion.
Bulletin du cancer - 1 Jan 1992
Mareel M, Vleminckx K, Vermeulen S, Bracke M, Van Roy F
Abstract excerpt
Invasion, eventually leading to metastasis, is presented as the result of a balance between the activation of 2 sets of genes, coined i+ (invasion promotor) and i- (invasion suppressor) genes. Experiments in vitro have indicated that the homotypic homophilic epithelial cell--cell adhesion molecule E-cadherin (L-CAM; uvomorulin; cell CAM 120/80; Arc-1; rrl antigen) is an i- gene product. In several cell families,...
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