Article
Expression of E-cadherin and specific CXCR3 isoforms impact each other in prostate cancer.
Cell communication and signaling : CCS - 12 Dec 2019
Ma Bo, Khazali Ahmad, Shao Hanshuang, Jiang Yuhan, Wells Alan
Abstract excerpt
BACKGROUND: Carcinoma cells shift between epithelial and mesenchymal phenotypes during cancer progression, as defined by surface presentation of the cell-cell cohesion molecule E-cadherin, affecting dissemination, progression and therapy responsiveness. Concomitant with the loss of E-cadherin during the mesenchymal transition, the predominant receptor isoform for ELR-negative CXC ligands shifts from CXCR3-B to...
Topics
- Animals
- Cadherins
- Down-Regulation
- Humans
- Male
- Mice
- Mice, Inbred NOD
- Mice, SCID
- Neoplasms, Experimental
- PC-3 Cells
- Phenotype
- Prostatic Neoplasms