Article
Donor G protein beta3 subunit 825TT genotype is associated with reduced kidney allograft survival.
Journal of the American Society of Nephrology : JASN - 1 Aug 1999
Beige J, Engeli S, Ringel J, Offermann G, Distler A, Sharma A M
Abstract excerpt
Recent studies have identified a novel polymorphism (C825T) of the gene encoding the beta3 subunit of heterotrimeric G proteins (Gbeta3), associated with enhanced activation of G proteins, which appears to be more common in hypertensive patients. In the present study, the relationship between this genetic variant and kidney allograft survival was examined over the first 3 yr after transplantation, in 320...
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