Article
G protein beta3 subunit 825T genotype is not associated with differing outcome in pediatric renal transplant recipients.
Pediatric transplantation - 1 Apr 2002
Hocher Berthold, Pleschka Aiko, Yang Fang, Kraus Rolf, Neumayer Hans-H, Filler Guido
Abstract excerpt
Recent studies have identified a novel polymorphism (C825T) of the gene encoding the beta3 subunit of heterotrimeric G proteins (GNB3), associated with enhanced activation of G proteins, which appears to be more common in hypertensive patients. The donor GNB3 825TT genotype was associated with reduced kidney allograft survival in adults. We examined (in 100 Caucasian pediatric renal transplant recipients) whether...
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