Article
G-protein beta3 subunit gene (GNB3) variant in causation of essential hypertension.
Hypertension (Dallas, Tex. : 1979) - 1 Dec 1998
Benjafield A V, Jeyasingam C L, Nyholt D R, Griffiths L R, Morris B J
Abstract excerpt
-Essential hypertensives display enhanced signal transduction through pertussis toxin-sensitive G proteins. The T allele of a C825T variant in exon 10 of the G protein beta3 subunit gene (GNB3) induces formation of a splice variant (Gbeta3-s) with enhanced activity. The T allele of GNB3 was shown...
Topics
- Age of Onset
- Australia
- Female
- GTP-Binding Proteins
- Genotype
- Humans
- Hypertension
- Male
- Middle Aged