Article
G-Protein beta(3) subunit C825T variant, nephropathy and hypertension in patients with type 2 (Non-insulin-dependent) diabetes mellitus.
American journal of nephrology - 1 Jan 2000
Zychma M J, Zukowska-Szczechowska E, Ossowska-Szymkowicz I, Trautsolt W, Grzeszczak W
Abstract excerpt
BACKGROUND: There is substantial evidence that hereditary factors contribute to the predisposition to diabetic nephropathy. On the other hand, it has been suggested that genetics of diabetic nephropathy and hypertension may overlap. Recently, a C to T substitution (C825T) in the gene encoding for the guanine-nucleotide-binding protein beta(3) subunit (GNB3) was identified, and this molecular variant was found to...
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