Evaluation of replication studies, combined data analysis, and analytical methods in complex diseases.

Abstract excerpt

Due to genetic heterogeneity, phenocopies, incomplete penetrance, misdiagnosis, and unknown mode of inheritance, linkage studies of most complex diseases are unlikely to provide conclusive findings with unambiguously high lod scores. Typically, several marginally significant lod scores or elevated lod scores are observed in a genome-wide screen. However, it is usually difficult to differentiate these findings...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Environment
• Share to Genetic Linkage
• Share to Genetic Markers