Article
Complete cDNA sequences of the DRB6 gene from humans and chimpanzees: a possible model of a stop codon readingthrough mechanism in primates.
Immunogenetics - 1 Sept 1999
Moreno-Pelayo M A, Fernández-Soria V M, Paz-Artal E, Ferre-López S, Rosal M, Morales P, Varela P, Arnaiz-Villena A
Abstract excerpt
The defective major histocompatibility complex (MHC) DRB6 gene is transcribed into mRNA in human [peripheral blood lymphocytes, transfected and Epstein-Barr virus (EBV)] and chimpanzee EBV cell lines. MHC-DRB6 presents several anomalies, which include stop codons in exon 2, lack of the usual polyadenilation signal of other MHC-DRB genes, and a promoter region and exon 1 taken from a locally inserted retrovirus....
Topics
- 3' Untranslated Regions
- Alleles
- Amino Acid Sequence
- Animals
- Base Sequence
- Cell Line
- Codon, Terminator
- Computer Simulation
- DNA Primers
- DNA, Complementary
- HLA-DR Antigens
- HLA-DR beta-Chains
- Humans