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Article

Loss of the TOR kinase Tor2 mimics nitrogen starvation and activates the sexual development pathway in fission yeast.

Molecular and cellular biology - 1 Apr 2007

Matsuo Tomohiko, Otsubo Yoko, Urano Jun, Tamanoi Fuyuhiko, Yamamoto Masayuki

Abstract excerpt

Fission yeast has two TOR (target of rapamycin) kinases, namely Tor1 and Tor2. Tor1 is required for survival under stressed conditions, proper G(1) arrest, and sexual development. In contrast, Tor2 is essential for growth. To analyze the functions of Tor2, we constructed two temperature-sensitive tor2 mutants. Interestingly, at the restrictive temperature, these mutants mimicked nitrogen starvation by arresting...

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Identifiers

PMID: 17261596
DOI: 10.1128/MCB.01039-06
PMCID: PMC1899950

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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