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Association between HLA alleles and haplotypes with age at diagnosis of type 1 diabetes in an admixed Brazilian population: A nationwide study.

HLA - 1 Jul 2024

Gomes Marília Brito, Dos Santos Gilson Costa, de Sousa Azulay Rossana Santiago, Santos Deborah Conte, Silva Dayse Aparecida, Carvalho Paulo Ricardo Vilas Boas, Negrato Carlos Antonio, Porto Luís Cristóvão

Abstract excerpt

To investigate the potential relationship between HLA alleles and haplotypes and the age at diagnosis of type 1 diabetes (T1DAgeD) in an admixed Brazilian population. This nationwide study was conducted in public clinics across 12 Brazilian cities. We collected demographic and genetic data from 1,600 patients with T1D. DNA samples were utilised to determine genomic ancestry (GA) and perform HLA typings for DRB1,...

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PMID: 38993161
DOI: 10.1111/tan.15574

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