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Article

HLA class I genes modulate disease risk and age at onset together with DR-DQ in Chinese patients with insulin-requiring type 1 diabetes.

Diabetologia - 1 Sept 2021

Jiang Ziyu, Ren Wenqian, Liang Hua, Yan Jinhua, Yang Daizhi, Luo Sihui, Zheng Xueying, Lin Guo-Wang, Xian Yingxin, Xu Wen, Yao Bin, Noble Janelle A, Bei Jin-Xin, Groop Leif, Weng Jianping

Abstract excerpt

AIMS/HYPOTHESIS: The study aimed to investigate the effects of HLA class I genes on susceptibility to type 1 diabetes with different onset ages, in addition to the well-established effects of HLA class II genes. METHODS: A total of 361 patients with type 1 diabetes (192 patients with onset <18 years and 169 patients with onset ≥18 years) and 500 healthy control participants from China were enrolled and genotyped...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34023962
DOI: 10.1007/s00125-021-05476-6
PMCID: PMC8382651

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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