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Article

Association of genetic variation with age at diagnosis in type 1 diabetes.

BMJ open diabetes research & care - 16 Jan 2026

Vollenbrock Charlotte E, Roshandel Delnaz, Lee Kristine E, Klein Barbara E, Mul Dick, van der Klauw Melanie M, Tack Cornelis J, Rewers Marian, Snell-Bergeon Janet K, Costacou Tina, Miller Rachel G, Caramori Maria Luiza, Mauer Mike, Aanstoot Henk-Jan, Wolffenbuttel Bruce H R, Paterson Andrew D

Abstract excerpt

INTRODUCTION: Type 1 diabetes is an autoimmune disease with a strong genetic basis. The aim of this study was to identify additional single-nucleotide polymorphisms (SNPs) for type 1 diabetes age at diagnosis and to replicate previously identified loci. RESEARCH DESIGN AND METHODS: Meta genome-wide association studies of age at diagnosis from eight cohorts (n=5910 in total) were performed in three models. Model 1...

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Identifiers

PMID: 41545229
DOI: 10.1136/bmjdrc-2023-003877
PMCID: PMC12815190

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