Article
High familial risk and genetic susceptibility in early onset childhood diabetes.
Diabetes - 1 Jan 2002
Gillespie Kathleen M, Gale Edwin A M, Bingley Polly J
Abstract excerpt
Early onset type 1 diabetes is associated with rapid beta-cell failure and high levels of HLA-mediated genetic susceptibility. We examined familial risk of disease in relation to age at onset in 1,299 families participating in the Bart's Oxford population-based family study of type 1 diabetes. Risk of diabetes was estimated by survival analysis in 1,430 siblings and 2,419 parents and related to age at onset in...
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