Article
Evidence of stage- and age-related heterogeneity of non-HLA SNPs and risk of islet autoimmunity and type 1 diabetes: the diabetes autoimmunity study in the young.
Clinical & developmental immunology - 1 Jan 2013
Frederiksen Brittni N, Steck Andrea K, Kroehl Miranda, Lamb Molly M, Wong Randall, Rewers Marian, Norris Jill M
Abstract excerpt
Previously, we examined 20 non-HLA SNPs for association with islet autoimmunity (IA) and/or progression to type 1 diabetes (T1D). Our objective was to investigate fourteen additional non-HLA T1D candidate SNPs for stage- and age-related heterogeneity in the etiology of T1D. Of 1634 non-Hispanic white DAISY children genotyped, 132 developed IA (positive for GAD, insulin, or IA-2 autoantibodies at two or more...
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