Article
Frequent expression of p53 protein without mutation in the atypical epithelium of human bronchus.
American journal of respiratory cell and molecular biology - 1 Aug 1999
Wakamatsu K, Nakanishi Y, Takayama K, Miyazaki H, Hayashi K, Hara N
Abstract excerpt
We investigated the correlation between p53 protein levels and mutations in the p53 gene of atypical bronchial epithelium (ABE). Protein levels were analyzed by immunohistochemistry, whereas mutations were assessed by polymerase chain reaction-single-strand conformational polymorphism (PCR-SSCP) and direct sequencing. A total of 78 formalin-fixed, paraffin-embedded bronchial biopsy specimens that had been...
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