Article
Epidermal growth factor receptor mutation and p53 overexpression during the multistage progression of small adenocarcinoma of the lung.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Jul 2010
Yoo Seol Bong, Chung Jin-Haeng, Lee Hyun Ju, Lee Choon-Taek, Jheon Sanghoon, Sung Sook Whan
Abstract excerpt
INTRODUCTION: A progression model of atypical adenomatous hyperplasia (AAH) to bronchioloalveolar carcinoma (BAC) to invasive adenocarcinoma (ADC) has been proposed. However, the genetic alterations of the AAH-BAC-ADC sequence are not clearly established. We examined the mutation of the epidermal growth factor receptor (EGFR) gene and p53 protein overexpression in the AAH, BAC, and small ADC to understand their...
Topics
- Adenocarcinoma
- Adenocarcinoma, Bronchiolo-Alveolar
- Adenomatosis, Pulmonary
- Adult
- Aged
- Aged, 80 and over
- Disease Progression
- ErbB Receptors
- Female
- Humans
- Immunoenzyme Techniques
- Lung Neoplasms
- Male