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Article

The specificity-conferring code of adenylation domains in nonribosomal peptide synthetases.

Chemistry & biology - 1 Aug 1999

Stachelhaus T, Mootz H D, Marahiel M A

Abstract excerpt

BACKGROUND: Many pharmacologically important peptides are synthesized nonribosomally by multimodular peptide synthetases (NRPSs). These enzyme templates consist of iterated modules that, in their number and organization, determine the primary structure of the corresponding peptide products. At the core of each module is an adenylation domain that recognizes the cognate substrate and activates it as its aminoacyl...

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Identifiers

PMID: 10421756
DOI: 10.1016/S1074-5521(99)80082-9

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