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Article

Structural basis of the interaction of MbtH-like proteins, putative regulators of nonribosomal peptide biosynthesis, with adenylating enzymes.

The Journal of biological chemistry - 18 Jan 2013

Herbst Dominik A, Boll Björn, Zocher Georg, Stehle Thilo, Heide Lutz

Abstract excerpt

The biosynthesis of nonribosomally formed peptides (NRPs), which include important antibiotics such as vancomycin, requires the activation of amino acids through adenylate formation. The biosynthetic gene clusters of NRPs frequently contain genes for small, so-called MbtH-like proteins. Recently, it was discovered that these MbtH-like proteins are required for some of the adenylation reactions in NRP...

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Identifiers

PMID: 23192349
DOI: 10.1074/jbc.M112.420182
PMCID: PMC3548506

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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