Article
Identification of a conserved N-terminal domain in the first module of ACV synthetases.
MicrobiologyOpen - 1 Jan 2021
Iacovelli Riccardo, Mózsik László, Bovenberg Roel A L, Driessen Arnold J M
Abstract excerpt
The l-δ-(α-aminoadipoyl)-l-cysteinyl-d-valine synthetase (ACVS) is a trimodular nonribosomal peptide synthetase (NRPS) that provides the peptide precursor for the synthesis of β-lactams. The enzyme has been extensively characterized in terms of tripeptide formation and substrate specificity. The first module is highly specific and is the only NRPS unit known to recruit and activate the substrate l-α-aminoadipic...
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