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Article

Two Control Elements in the Hepatitis B Virus S–Promoter Are Important for Full Promoter Activity Mediated by Ccaat–Binding Factor

1 Apr 1999

Abstract excerpt

Natural occurring mutations in the preS-region are frequently found during chronic hepatitis B virus (HBV) infection. Here we used the mutated preS-region from a patient to study the transcriptional regulation of the S-promoter. The mutations were a CCAAT-box (MUT1) point mutation, a 6-base pair (bp) deletion (MUT2) 3' of the CCAAT-box, and a 153 bp deletion (MUT3) in the preS2 genome. Transfection experiments...

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Identifiers

PMID: 10094970
DOI: 10.1002/hep.510290426

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