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Article

A hepatitis B virus variant found in the sera of immunised children induces a conformational change in the HBsAg "a" determinant.

Journal of medical virology - 1 Aug 1999

Karthigesu V D, Allison L M, Ferguson M, Howard C R

Abstract excerpt

The emergence of variants in the outer envelope proteins of hepatitis B virus (HBV) are found among individuals vaccinated against HBV and asymptomatic carriers of the infection. For example, children in The Gambia vaccinated against hepatitis B may show serological evidence of breakthrough infections, particularly if anti-HBs antibodies induced by the vaccine are low in titre. A single-point mutation at...

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Identifiers

PMID: 10421400
DOI: 10.1002/(sici)1096-9071(199908)58:4<346::aid-jmv5>3.0.co;2-7

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