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Article

Antiviral resistance mutations potentiate hepatitis B virus immune evasion through disruption of its surface antigen a determinant.

Antiviral therapy - 1 Jan 2008

Sloan Richard D, Ijaz Samreen, Moore Penny L, Harrison Tim J, Teo Chong-Gee, Tedder Richard S

Abstract excerpt

BACKGROUND: The hepatitis B virus (HBV) pol gene overlaps the S gene encoding surface antigen (HBsAg). It has been reported previously that drug-induced changes in HBsAg alter its binding to sera from humans immunized against HBV. We investigate here the changes to specific epitopes in the a determinant (the major target of neutralizing antibody) caused by a number of drug-resistant mutations. METHODS:...

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Share to Antigen-Antibody Reactions
Share to Drug Resistance, Multiple, Viral

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Gene Products, pol

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Source

Identifiers

PMID: 18572757

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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