Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Reduced expression of cyclooxygenase 2 proteins in hereditary nonpolyposis colorectal cancers relative to sporadic cancers.

Gastroenterology - 1 Aug 1999

Sinicrope F A, Lemoine M, Xi L, Lynch P M, Cleary K R, Shen Y, Frazier M L

Abstract excerpt

BACKGROUND & AIMS: Cyclooxygenase (COX) enzymes catalyze the conversion of arachidonic acid to prostaglandins. Evidence suggests that nonsteroidal anti-inflammatory drugs reduce the risk of colorectal cancer (CRC) and that this effect is mediated through COX inhibition. We analyzed and compared e...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenomatous Polyposis Coli
Share to Colorectal Neoplasms, Hereditary Nonpolyposis
Share to Cyclooxygenase 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclooxygenase 2 Inhibitors

Share to Cyclooxygenase Inhibitors

Share to Isoenzymes

Share to Prostaglandin-Endoperoxide Synthases

Share to Receptors, Transforming Growth Factor beta

Source

Identifiers

PMID: 10419916
DOI: 10.1053/gast.1999.0029900350

Genes

FAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-10419916-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Reduced expression of cyclooxygenase 2 proteins in hereditary nonpolyposis colorectal cancers relative to sporadic cancers.PMID 10419916Read ↗

Increased cyclooxygenase-2 expression in duodenal compared with colonic tissues in familial adenomatous polyposis and relationship to the -765G -> C COX-2 polymorphism.Semantic proximity Read ↗

Cyclooxygenase 2 Expression in Colorectal Cancer with DNA Mismatch Repair DeficiencySemantic proximity Read ↗

Cyclooxygenase 2 expression and molecular alterations in Peutz-Jeghers hamartomas and carcinomas.Semantic proximity Read ↗

Prevention of colorectal cancer using COX-2 inhibitors: basic science and clinical applications.Semantic proximity Read ↗

Targeting cyclooxygenase‐2 for prevention and therapy of colorectal cancerSemantic proximity Read ↗

Differential stromal and epithelial localization of cyclooxygenase-2 (COX-2) during colorectal tumorigenesis.Semantic proximity Read ↗

The role of COX-2 in intestinal cancer.Semantic proximity Read ↗

Regulation of Constitutive Cyclooxygenase-2 Expression in Colon Carcinoma CellsSemantic proximity Read ↗

Cell cycle regulators and apoptosis-associated proteins in relation to proliferative activity and degree of apoptosis in HNPCC versus sporadic endometrial carcinoma.Semantic proximity Read ↗

Expression of transforming growth factor beta receptors in normal human colon and sporadic adenocarcinomas.Semantic proximity Read ↗

Cyclooxygenase-2 expression in human colon cancer cells increases metastatic potentialSemantic proximity Read ↗

Aberrant methylation of the Cyclooxygenase 2 CpG island in colorectal tumors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.