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Cyclooxygenase 2 Expression in Colorectal Cancer with DNA Mismatch Repair Deficiency

15 Mar 2006

Abstract excerpt

BACKGROUND: Cyclooxygenase 2 (COX-2) overexpression is a frequent but not universal event in colorectal cancer. It has been suggested that COX-2 protein expression is reduced in colorectal cancer with a defective mismatch repair (MMR) system, a phenomenon commonly associated with hereditary nonpolyposis colorectal cancer (HNPCC) but also present in up to 15% of sporadic tumors. AIM: To assess COX-2 expression in...

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PMID: 16551850
DOI: 10.1158/1078-0432.ccr-05-1581

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