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Article

The kinetics of epithelial cell generation: its relevance to cancer and ageing.

Journal of theoretical biology - 7 Jul 1999

Morris J A

Abstract excerpt

A hierarchical model of epithelial cell generation is proposed, in which even in extreme old age mature epithelial cells in humans are only a limited number of cell divisions from the zygote (60-120). This contrasts with conventional models in which regularly cycling stem cells can be several thousands of cell divisions from the zygote. The hierarchical model is supported by data on the rate of telomere...

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Identifiers

PMID: 10419761
DOI: 10.1006/jtbi.1999.0943

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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