Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Somatic stem cells and the kinetics of mutagenesis and carcinogenesis

29 Jul 2002

Abstract excerpt

There is now strong experimental evidence that epithelial stem cells arrange their sister chromatids at mitosis such that the same template DNA strands stay together through successive divisions; DNA labeled with tritiated thymidine in infancy is still present in the stem cells of adult mice even though these cells are incorporating (and later losing) bromodeoxyuridine [Potten, C. S., Owen, G., Booth, D. & Booth,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Genomics and Diagnostics
Share to DNA Repair Mechanisms
Share to Genetic factors in colorectal cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 12149477
DOI: 10.1073/pnas.162369899

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Somatic stem cells and the kinetics of mutagenesis and carcinogenesisPMID 12149477Read ↗

Intestinal stem cells protect their genome by selective segregation of template DNA strands.Semantic proximity Read ↗

Stem Cell DNA Damage and Genome Mutation in the Context of Aging and Cancer Initiation.Semantic proximity Read ↗

The (not so) immortal strand hypothesisSemantic proximity Read ↗

Effect of stem cell turnover rates on protection against cancer and aging.Semantic proximity Read ↗

Stem cell aging and cancer.Semantic proximity Read ↗

Why do stem cells exist?Semantic proximity Read ↗

The Stem Cell Division Theory of CancerSemantic proximity Read ↗

The stem cell division theory of cancer.Semantic proximity Read ↗

The immortal strand hypothesis: segregation and reconstruction.Semantic proximity Read ↗

Intestinal epithelial stem cells do not protect their genome by asymmetric chromosome segregationSemantic proximity Read ↗

Ancestral trees for modeling stem cell lineages genetically rather than functionally: understanding mutation accumulation and distinguishing the restrictive cancer stem cell propagation theory and the unrestricted cell propagation theory of human tumorigenesis.Semantic proximity Read ↗

Variation of mutational burden in healthy human tissues suggests non-random strand segregation and allows measuring somatic mutation ratesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.