Cancer Risk and the Somatic Cell Lineage Tree

Abstract excerpt

All the cells of a multicellular organism are the product of cell divisions that trace out a single binary tree, the so-called cell lineage tree. Because cell divisions are accompanied by replication errors, the shape of the cell lineage tree is one of the key determinants of how somatic evolution, which can potentially lead to cancer, proceeds. Cancer initiation usually requires the accumulation of a certain numb...

Topics

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• Biological Evolution
• Cell Lineage
• Cell Proliferation
• Models, Biological
• Models, Genetic
• Mutation
• Mutation Accumulation
• Neoplasms

Identifiers and source

Literature Corpus work

964e2afd-42f9-5606-9394-567ed22d1eeb

DOI

10.1101/2020.07.13.201004