Article
Epithelial Cell Transformation and Senescence as Indicators of Genome Aging: Current Advances and Unanswered Questions.
International journal of molecular sciences - 14 Jul 2021
Kitakaze Masatoshi, Chijimatsu Ryota, Vecchione Andrea, Kitagawa Toru, Doki Yuichiro, Eguchi Hidetoshi, Ishii Hideshi
Abstract excerpt
The recent advances in deciphering the human genome allow us to understand and evaluate the mechanisms of human genome age-associated transformations, which are largely unclear. Genome sequencing techniques assure comprehensive mapping of human genetics; however, understanding of gene functional interactions, specifically of time/age-dependent modifications, remain challenging. The age of the genome is defined by...
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