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Article

Differences in left-right axis pathways in mouse and chick: functions of FGF8 and SHH.

Science (New York, N.Y.) - 16 Jul 1999

Meyers E N, Martin G R

Abstract excerpt

A molecular pathway leading to left-right asymmetry in the chick embryo has been described, in which FGF8 is a right determinant and Sonic Hedgehog a left determinant. Here evidence is presented that the Fgf8 and Sonic Hedgehog genes are required for left-right axis determination in the mouse embryo, but that they have different functions from those previously reported in the chick. In the mouse FGF8 is a left...

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Source

Identifiers

PMID: 10411502
DOI: 10.1126/science.285.5426.403

Genes

FGF8
SHH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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