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Article

Left cardiac isomerism in the Sonic hedgehog null mouse

22 May 2009

Abstract excerpt

Sonic hedgehog (Shh) is a secreted morphogen necessary for the production of sidedness in the developing embryo. In this study, we describe the morphology of the atrial chambers and atrioventricular junctions of the Shh null mouse heart. We demonstrate that the essential phenotypic feature is isomerism of the left atrial appendages, in combination with an atrioventricular septal defect and a common...

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Share to Congenital Anomalies and Fetal Surgery
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PMID: 19538633
DOI: 10.1111/j.1469-7580.2009.01087.x

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