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Article

The impact of APOE on myocardial infarction, stroke, and dementia: the Rotterdam Study.

Neurology - 13 Apr 2004

Slooter A J C, Cruts M, Hofman A, Koudstaal P J, van der Kuip D, de Ridder M A J, Witteman J C M, Breteler M M B, Van Broeckhoven C, van Duijn C M

Abstract excerpt

It is unclear how the APOE genotype contributes to the incidence of vascular diseases and dementia. In a population-based sample (n = 6,852) with complete follow-up, APOE was weakly associated with myocardial infarction and not related with stroke. In the absence of epsilon4, the incidence of dementia would be 25.8% lower; in the absence of epsilon2/epsilon3, 2.8% higher. Risk estimates of dementia, specified for...

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Source

Identifiers

PMID: 15079025
DOI: 10.1212/01.wnl.0000118302.66674.e1

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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The impact of APOE on myocardial infarction, stroke, and dementia: the Rotterdam Study.PMID 15079025Read ↗

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APOE genotype predicts AD and other dementia but not ischemic cerebrovascular disease.Semantic proximity Read ↗

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APOE-ε4 Genotype and Dementia Before and After Transient Ischemic Attack and Stroke: Population-Based Cohort Study.Semantic proximity Read ↗

Apolipoprotein E genotype, cardiovascular biomarkers and risk of stroke: systematic review and meta-analysis of 14,015 stroke cases and pooled analysis of primary biomarker data from up to 60,883 individuals.Semantic proximity Read ↗

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Does apolipoprotein E genotype influence the risk of ischemic stroke, intracerebral hemorrhage, or subarachnoid hemorrhage? Systematic review and meta-analyses of 31 studies among 5961 cases and 17,965 controls.Semantic proximity Read ↗

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