Article
T-cell receptor vbeta deletion and valpha polymorphism are responsible for the resistance of SWR mouse to arthritis induction.
Immunogenetics - 1 Aug 1999
Osman G E, Hannibal M C, Anderson J P, Cheunsuk S, Lasky S R, Liggitt H D, Ladiges W C, Hood L E
Abstract excerpt
Collagen type II-induced arthritis (CIA) develops in susceptible mouse strains after intradermal injections of type II collagen (CII) in complete Freund's adjuvant (CFA). Susceptibility to CIA in mice is linked to genes of the major histocompatibility complex (MHC). Although the SWR mouse has a susceptible MHC haplotype (H2q), it is resistant to CIA. SWR exhibits at least two known immunological defects: (1) it...
Topics
- Animals
- Arthritis
- B-Lymphocytes
- Collagen
- Epitopes
- Gene Deletion
- Genetic Predisposition to Disease
- Immunoglobulin Variable Region
- Joints
- Mice
- Mice, Inbred DBA
- Mice, Inbred Strains
- Mice, Transgenic
- Molecular Sequence Data