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Article

The role of C5 and T-cell receptor Vb genes in susceptibility to collagen-induced arthritis.

Immunogenetics - 1 Jan 1991

Spinella D G, Jeffers J R, Reife R A, Stuart J M

Abstract excerpt

Collagen-induced arthritis (CIA) is a rodent arthritis model in which immunization with heterologous type II collagen induces an inflammatory polyarthritis. Susceptibility to the disease is mediated by major histocompatibility complex (MHC) genes as well as genes at other loci. Previous studies of the SWR/J mouse strain, which is resistant to CIA despite bearing the susceptible H-2q haplotype, have suggested that...

Topics

Analysis of Variance
Animals
Arthritis
Chromosome Deletion
Collagen
Complement C5
Disease Models, Animal
Disease Susceptibility
Genetic Predisposition to Disease
Genotype
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptors, Antigen, T-Cell

Source

Identifiers

PMID: 1855815
DOI: 10.1007/BF00212308

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1855815-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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