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Article

Effects of p21cip1/waf1 overexpression on growth, apoptosis and differentiation in human colon carcinoma cells.

International journal of oncology - 1 Jul 2005

Izawa Hikaru, Yamamoto Hirofumi, Damdinsuren Bazarragchaa, Ikeda Kimimasa, Tsujie Masaki, Suzuki Rei, Kitani Kotaro, Seki Yosuke, Hayashi Taro, Takemasa Ichiro, Ikeda Masataka, Ohue Masayuki, Sekimoto Mitsugu, Monden Takushi, Monden Morito

Abstract excerpt

The cyclin-dependent kinase inhibitor p21cip1/waf1 negatively regulates the progression of cell cycle and the potential usefulness of p21cip1/waf1 gene is proposed in gene therapy. However, studies have demonstrated a protective role of p21cip1/waf1 against apoptosis and little is known about effects of ectopic expression of p21cip1/waf1 on differentiation of colon cancer cells. In the present study, we found...

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PMID: 15942645

Genes

CDK2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Effects of p21cip1/waf1 overexpression on growth, apoptosis and differentiation in human colon carcinoma cells.PMID 15942645Read ↗

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p21WAF1/CIP1 expression in colorectal carcinoma correlates with advanced disease stage and p53 mutations.Semantic proximity Read ↗

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Mutated p21(WAF1/CIP1/SDI1) lacking CDK-inhibitory activity fails to prevent apoptosis in human colorectal carcinoma cells.Semantic proximity Read ↗

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Inactivation of p21Sensitizes Cells to Apoptosis via an Increase of Both p14ARF and p53 Levels and an Alteration of the Bax/Bcl-2 RatioSemantic proximity Read ↗

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