Article
Tuning somatic hypermutation by transcription.
Current topics in microbiology and immunology - 1 Jan 1999
Jacobs H, Puglisi A, Rajewsky K, Fukita Y
Abstract excerpt
The dependence of somatic hypermutation on transcription was studied in three mutant immunoglobulin heavy chain (IgH) insertion mice in which a targeted non-functional VHB1-8 passenger transgene was either placed under the transcriptional control of a truncated DQ52 promoter (p delta), its own RNA polymerase II dependent IgH promoter (pII) or a RNA polymerase I dependent promoter (pI). The relative...
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