Article
Somatic hypermutation in the heavy chain locus correlates with transcription.
Immunity - 1 Jul 1998
Fukita Y, Jacobs H, Rajewsky K
Abstract excerpt
Three mutant immunoglobulin heavy chain (IgH) insertion mice were generated in which a targeted nonfunctional IgH passenger transgene was either devoid of promoter (pdelta) or was placed under the transcriptional control of either its own RNA polymerase II-dependent IgH promoter (pII) or a RNA po...
Topics
- Animals
- Female
- Germinal Center
- Immunoglobulin Heavy Chains
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C57BL
- Mutation
- Poly A
- Promoter Regions, Genetic
- RNA Polymerase I
- RNA Polymerase II
- RNA Precursors
- Transcription, Genetic