Article
Somatic hypermutation in the heavy chain locus correlates with transcription.
Immunity - 1 Jul 1998
Fukita Y, Jacobs H, Rajewsky K
Abstract excerpt
Three mutant immunoglobulin heavy chain (IgH) insertion mice were generated in which a targeted nonfunctional IgH passenger transgene was either devoid of promoter (pdelta) or was placed under the transcriptional control of either its own RNA polymerase II-dependent IgH promoter (pII) or a RNA polymerase I-dependent promoter (pI). While the transgene mutation-frequency (0.85%) in memory B cells of pI mice was...
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